Assionob



Reiuued Jan. 24, 1933 UNITED STATES PATENT orrrca BENJAMIN I. EIOHER, OICH IGAGO, ILLINOIS, ABSIGNOB, BY MESNE ASSIGNMENTS, TO

THE DR. GROSS LABORATORIB, INC., DAYTON, OHIO, A CORPORATION 01 DELL-WARE PROCESS FOR MAKING GOD-LIYER-OII: TABLETS Il'o Drawing. OriginalNo. 1,552,549, dated September 8, 1925, herial No. 712,555, filed Kay12, 1924.

Application for reissue flled January 15, 1928. Serialll'o. 81 569.

This invention relates to the manufacture of pills, more particularlypills having an oily material as one of the principal'ingredients.

5 One of the difficulties hitherto encountered in connection with makinpills is the incorporation with the other mgredients-of oily materialssuch as cod liver oil extractives, i. e. the ethereal, alcoholic andother well known extractives of the active components of cod liver oil.

It is an object, therefore, of the present invention to rovide animproved process for making pill more particularly pills having 5 an oilmaterial as one of the dients.

Other and further important objects of the invention will be apparentfrom the disclosures in the followin description, which sets forth thepreferred orm of the invention.

According to the preferred form of the invention reduced iron, zincphosphide, berberine sulphate and strychnine sulphate are mixed in aball'mill with suflicient charcoal to get a thorough mixture. Thebalance of the charcoal desired is then added and uniformly incorporatedin the mixture. Then principal ingrea solution of oleoresin of ginger inether is added and the whole thorou hly mixed. The next step is toreduce t e material into anular form which may conveniently be one bypassin it through a screen. The granules so ma e are dried and thenagain passed through the screen and compressed 5 mto three ancompression step the pressure should not be greater than is retl uiredto make a coherent mass since the pil s should be rous to absorb asolution of cod-liver o1l extractives in a volatile solvent.

The ills after compression are placed in a perco ator and a solution ofcod-liver oil extractives in about twice their wei ht of ether is pouredover the pills. The so ution flowing through the percolator is caughtand reone-half grain tablets. In the passed through the pills until allhas beenabsorbed. The pills are then dried at a suitable temperature toremove the volatile solvent when they are ready to coat.

The pills may conveniently be coated in a pan with simple syrup. Next athin coating of dry powdered (granulated) acacia is applied. The pillsare dried and the coating operations are repeated. After further dryingthey are sugar coated brown or any other desired color.

The proportion ,of the ingredients used is preferably kept'within thefollowing limits:

I Per cent Cod liver oil extractives 7 to 30' Reduced iron 1 to 8 Zinc'phosphide 0.5 to 3 Berberine sulphate r 0.1 to 0.6

Strychnine sulphate 0.01 to 0.06 Oleoresin of ginger 0.1 to. 0.6Powdered charcoal 5O to Proportions which have been found especiallysuitable are the following:

Various of these ingredients may be omitted if desired without changingthe proc ess in any way. Further, other absorbent materials thancharcoal may in some cases be :employed. Also other volatile solventsthan ether may be used in certain cases.

It will also be evident that several of the numerous steps in theprocess may be omitted or modified without changing the essentialprinciples of the invention. Thus in place of a percolator the pills andsolution of codliver oil extractives might be placed in a tumblingbarrel to incorporate the latter in the ills. A percolator is preferred,however, as there is less tendency to break the pills.

I am aware that numerous details of this process may be varied through awide range without departin from the principles oi this invention, andtherefore do not purpose limiting the patent granted, otherwise thannecessitated by the prior art.

Having now described my invention, I claim 1. A process for making pillscomprising forming charcoal pills, then applying to the pills a solutionof cod liver oil extractives in a volatile solvent and evaporating thesolvent.

forming charcoal pills, then applying to the pills a solution ofcod-liver oil extractives in ether and evaporating the ether.

3. A process for making pills comprising .mixing charcoal with asolution of oleoresin phide, berberine sulphate and strychnine sulphate,and a solution of oleoresin of ginger in ether, granulating and dryingthe mixture, forming the dry mixture into pills by pressure, thenapplying to the pills a solution of cod liver oil extractives in etherand evapor-' ating the ether.

5. A method of forming a dry medicinal agent containing active extractedingredients of cod-liver oil, which consists in causing a solution ofsaid active ingredients to come into contact with a porous inert carrierwhich is insoluble in water, and allowing the solvent in said solutionto evaporate at a suitable temperature.

. 6. A method of forming a dry medicinal agent containing activeextracted ingredients of cod-liver oil, which consists in causing asolution of said active ingredients in ether to come into contact with aporous inert carrier which is insoluble in water, and allowing thesolvent in said solution to evaporate at a suitable temperature.

7. A method of forming a dry medicinal agent in coherent tablet form andcontaining active extracted ingredients of cod-liver oil, which consistsin causing connected particles of a porous inert carrier which isinsoluble in water to contactwith a solution of said active ingredients,allowingthe solvent in said solution to evaporate at a suitabletemperature, and binding said particles by a suitable binder whoseaction is efiective at a suitable temperature.

2. A process for making pills comprising 8. A medicinal. ent comprisinga porous inert carrier insold le in water and containing the absorbedresidue from an evaporated sollution of the active ingredients ofcod-liver o1 9. A medicinal agent comprising tablet' made of particlesof a porous inert carrying material insoluble in water, said carryingmaterial containing the absorbed residue gradients, forming the mixtureinto pill form,

applying to the pills thus formed a solution of cod liver oilextractives in ether, and evapo rating the ether.

12. The method of makin pills which comprises mixing together medicinalingredients with a sufiicient volume of an inert absorbent materialinsoluble water to enable a thorough mixture, then addin more of saidabsorbent material and uni ormly incorporatin the same in the mixture,then adding a so ution of a binding ingredient in a volatile solvent andthoroughly mixing the whole, forming the final mixture into pill formwith just enough pressure to produce a coherent mass for each pill, soas not to destroy its porosity, then treating the pills thus formed witha solution of cod liver oil extractives in a volatile solvent, andevaporating the solvent.

13. A method of making cod liver oil pills comprisin forming the pillsfrom a mass 0 an inert a sorbent material insoluble in water, and inwhich a solution of cod liver oil extractives is absorbed. V

14. A medicinal agent in tablet form and composed of an inert andabsorbent excipient which is insoluble in water, and an absorbedextractive of cod liver oil contained in said exc'ipient.

15. A process for makin mixing charcoal with mediclnal ingredients,forming the mixture into pill form, then applying to the pills asolution of an ingredient containing the therapeutic principles of codliver oil in a volatile solvent, and evaporating the solvent.

16. A process for making pills comprising forming pill bodies of aninert absorbent material insoluble in water, then applying to the pillsa solution of a medicinal ingredient containing extractives of cod liveroil in a volatile solvent, and evaporating the solvent.

ills comprising 17. The process of preparing cod liver oil in pill ortablet form comprisl 1provi a solution of there utic princi es of liveroil in a volati e solvent,- an absorbing 6 said solution in an inertabsorbent exoipient insoluble in water and from which the pills ortablets are formed, and allowing the solvent to evaporate, so that saidtherapeutic principles are retained in the exci iient sub- 10 stanceafter evaporation of the v0 atile solvent.

In witnes whereof I hereunto subscribe my name to this specification. Y

15 "BENJAMIN L. EICHER. l

